Analytical Data
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Gene name
MT1A
- Application
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Alternative Names
MT1A；MT1S；Metallothionein-1A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04731
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Expression Region
1-59aa
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AA Sequence
MDPNCSCATGGSCTCTGSCKCKECKCTSCKKSCCSCCPMSCAKCAQGCICKGASEKCSC
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Molecular Weight
32.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MT1A (metallothionein 1A) is a member of the metallothionein family, which consists of low-molecular-weight proteins characterized by their high cysteine content and ability to bind metal ions. The primary function of MT1A is to regulate cellular metal homeostasis, detoxify heavy metals, and protect cells from oxidative stress. Research has indicated that MT1A plays a crucial role in various physiological processes, including metal ion transport, antioxidant defense, and cellular signaling. Dysregulation of MT1A expression has been linked to several diseases, including cancer, neurodegenerative disorders, and conditions related to metal toxicity. As a consequence, understanding the mechanisms governing MT1A expression and function is of significant interest in biomedical research. Scientists are exploring MT1A as a potential biomarker for disease progression and as a therapeutic target, particularly in the context of metal-related pathologies and oxidative stress-associated disorders. Additionally, advances in recombinant protein technology have facilitated the production of MT1A for structural and functional studies, providing insights into its interactions with various metal ions and its role in cellular mechanisms. Overall, the comprehensive study of MT1A is essential for elucidating its biological significance and potential applications in clinical settings.
