Analytical Data
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Gene name
TMPRSS11B
- Application
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Alternative Names
TMPRSS11B；HATL5；Transmembrane protease serine 11B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86T26
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Expression Region
39-416aa
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AA Sequence
LAVEKTYYYQ GDFHISGVTY NDNCENAAS QASTNLSKDI ETKMLNAFQN SSIYKEYVKS EVIKLLPNAN GSNVQLQLKF KFPPAEGVS MRTKIKAKLH QMLKNNMASW NAVPASIKLM EISKAASEML TNNCCGRQVA NSIITGNKI VNGKSSLEGA WPWQASMQWK GRHYCGASLI SSRWLLSAAH CFAKKNNSKD WTVNFGIVV NKPYMTRKVQ NIIFHENYSS PGLHDDIALV QLAEEVSFTE YIRKICLPEA KMKLSENDN VVVTGWGTLY MNGSFPVILQ EDFLKIIDNK ICNASYAYSG FVTDTMLCAG FMSGEADAC QNDSGGPLAY PDSRNIWHLV GIVSWGDGCG KKNKPGVYTR VTSYRNWITS KTGL
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Molecular Weight
44 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMPRSS11B, a member of the type II transmembrane serine protease family, has garnered attention due to its potential roles in various physiological and pathological processes. Originally identified for its involvement in the activation of certain viral glycoproteins, TMPRSS11B is believed to play a significant role in modulating viral infections and has been linked to the infection pathways of viruses such as influenza and coronaviruses. Moreover, its expression is observed in various human tissues, indicating it may also be involved in normal physiological functions. Research into TMPRSS11B has expanded to explore its implications in cancer biology, as aberrant protease activity can contribute to tumor progression and metastasis. The recombinant expression of TMPRSS11B provides a valuable tool for studying its enzymatic characteristics, substrate specificity, and interactions with other proteins. This knowledge is crucial for understanding its biological functions and developing therapeutic strategies targeting TMPRSS11B-related pathways. As a result, ongoing studies aim to elucidate the detailed mechanisms by which TMPRSS11B influences health and disease, thus highlighting its potential as a therapeutic target or biomarker in various clinical contexts.
