Analytical Data
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Gene name
Ikzf2
- Application
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Alternative Names
Ikzf2；HELIOS；ZNFN1A2；Zinc finger Protein Helios
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UKS7
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Expression Region
1-500aa
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AA Sequence
METEAIDGYITCDNELSPEREHSNMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRKPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQELQGEGGIRLPNGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTGNMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHPPSTIAEVAPVISSAYSQVYHPNRIERPISRETADSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDHQSYQGHPALNPKRKQSPAYMKEDVKALDTTKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH
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Molecular Weight
59.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Ikzf2, also known as Ikaros, is a member of the Ikaros family of zinc finger proteins that play crucial roles in the development and regulation of the immune system, particularly in T and B cell differentiation. Research has shown that Ikzf2 is essential for proper lymphocyte function, as it regulates gene expression critical for immune response and cell fate determination. Dysregulation of Ikzf2 has been implicated in various hematological malignancies, including leukemia and lymphoma, making it a potential target for therapeutic intervention. The recombinant expression of Ikzf2 protein allows for the detailed study of its structure, function, and interactions with other cellular components. Understanding these interactions can provide insights into the mechanisms underlying immune system regulation and the pathogenesis of related diseases. Furthermore, generating recombinant Ikzf2 enables the development of assays to screen for small molecules or other compounds that may modulate its activity, offering new avenues for targeted therapies in cancer treatment. Overall, the research on Ikzf2 recombinant protein is significant for both basic immunology and clinical applications, shedding light on potential strategies for manipulating immune responses in various disease contexts.
