Analytical Data
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Gene name
Cxcl12
- Application
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Alternative Names
Cxcl12；C-X-C chemokine receptor type 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48061
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Expression Region
22-89aa
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AA Sequence
KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNK
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Molecular Weight
8.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCL12, also known as stromal cell-derived factor-1 (SDF-1), is a chemokine that plays a crucial role in various physiological and pathological processes, including cell migration, hematopoiesis, and immune response. It primarily exerts its effects through binding to its receptor CXCR4, influencing the migration of hematopoietic stem cells, lymphocytes, and progenitor cells to their respective niches. Given its significant involvement in cancer metastasis, inflammatory diseases, and tissue regeneration, the study of CXCL12 has garnered considerable attention. Recombinant CXCL12 protein has become a valuable tool in research, allowing scientists to investigate its functional mechanisms in vitro and in vivo. By providing an easily accessible source of this important protein, recombinant CXCL12 facilitates the exploration of its therapeutic potential, particularly in modulating immune responses and enhancing tissue repair. Additionally, understanding CXCL12's role in tumor microenvironments has opened avenues for developing targeted therapies for cancer treatment. Current research is focused on optimizing the production of recombinant CXCL12, characterizing its biological activity, and exploring its interactions with various cell types. Overall, the study of recombinant CXCL12 is pivotal for unraveling its complex roles in health and disease, potentially leading to novel therapeutic strategies for diverse conditions.
