Analytical Data
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基因名
GNB5
- Application
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别名
GNB5；Guanine nucleotide-binding Protein subunit beta-5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14775
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表达区间
1-353aa
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氨基酸序列
MATEGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
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分子量
54.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNB5, a member of the G-protein beta subunit family, plays a critical role in various signaling pathways and is pivotal for the function of G-proteins in eukaryotic cells. The functional implications of GNB5 have garnered attention due to its involvement in the regulation of ion channels, neurotransmitter release, and sensory perception. Dysregulation of GNB5 expression has been linked to several neurodevelopmental disorders and cardiovascular diseases, highlighting its potential as a therapeutic target. Recent studies have focused on the recombinant expression of GNB5 to elucidate its structural and functional properties, which are essential for understanding its role in cellular signaling. By producing GNB5 as a recombinant protein, researchers aim to explore its interaction with G-protein coupled receptors (GPCRs) and decipher the molecular mechanisms governing its function. This could lead to significant advancements in drug development and therapeutic strategies targeting GNB5-related pathologies. The ongoing research surrounding GNB5 recombinant protein not only contributes to the understanding of G-protein signaling dynamics but also offers insights into the intricate networks of cellular communication, ultimately paving the way for innovative treatments for diseases associated with GNB5 dysregulation.
