Analytical Data
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基因名
CLIC5
- Application
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别名
CLIC5；Chloride intracellular channel Protein 5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZA1
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表达区间
1-251aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMTDSATANGDDRDPEIELFVKAGIDGESIG NCPFSQRLFM ILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEE FLEETLTPEK YPKLAAKHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALKKLDD YLNTPLPEEI DANTCGEDKGSRRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAE MTGLWRYLKN AYARDEFTNTCAADSE
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分子量
27 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CLIC5 (Chloride Intracellular Channel 5) is a member of the CLIC (Chloride Intracellular Channel) protein family, known for its pivotal roles in maintaining cellular chloride ion homeostasis and regulating various physiological processes. Recent research emphasizes the significance of CLIC5 in cardiovascular and renal function, as well as its involvement in cell migration and proliferation. Dysregulation of CLIC5 has been associated with several pathological conditions, including hypertension, kidney diseases, and cancer. Given its critical functions, there is an increasing interest in developing recombinant CLIC5 proteins for functional studies, structural analysis, and potential therapeutic applications. The production of a properly folded and functional recombinant CLIC5 protein is essential for elucidating its mechanisms of action, interactions with other cellular components, and its role in health and disease. Such studies aim to provide insights into its biological significance and pave the way for novel therapeutic strategies targeting CLIC5 in various diseases, underscoring the need to investigate its structure-function relationship comprehensively.
