Analytical Data
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基因名
GNAT2
- Application
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别名
GNAT2；GNATC；Guanine nucleotide-binding Protein G(t) subunit alpha-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P19087
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表达区间
2-354aa
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氨基酸序列
GSGASAEDK ELAKRSKELE KKLQEDADKE AKTVKLLLLG AGESGKSTIV KQMKIIHQDG YSPEECLEFK AIIYGNVLQS ILAIIRAMTT LGIDYAEPSC ADDGRQLNNL ADSIEEGTMP PELVEVIRRL WKDGGVQACF ERAAEYQLND SASYYLNQLE RITDPEYLPS EQDVLRSRVK TTGIIETKFS VKDLNFRMFD VGGQRSERKK WIHCFEGVTC IIFCAALSAY DMVLVEDDEV NRMHESLHLF NSICNHKFFA ATSIVLFLNK KDLFEEKIKK VHLSICFPEY DGNNSYDDAG NYIKSQFLDL NMRKDVKEIY SHMTCATDTQ NVKFVFDAVT DIIIKENLKD CGLF
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分子量
40.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNAT2 (Guanylate Nucleotide-binding Protein 2) is a member of the G protein family, playing a significant role in the signaling pathways of phototransduction in vertebrate photoreceptor cells. This protein is essential for the proper functioning of rod and cone cells in the retina, where it facilitates the conversion of light into electrical signals, thereby influencing vision. Research on GNAT2 and its recombinant forms has gained prominence due to its implications in various retinal diseases, such as retinitis pigmentosa and Leber congenital amaurosis, which are characterized by the degeneration of photoreceptor cells. Understanding the structure and function of GNAT2, particularly through the study of recombinant protein, provides insights into the molecular mechanisms underlying these conditions. The use of recombinant GNAT2 in laboratory settings enables researchers to conduct functional assays, investigate protein interactions, and explore the potential for gene therapy approaches to restore vision in affected individuals. The ongoing studies aim to elucidate the precise role of GNAT2 in visual signal transduction and advance therapeutic strategies, making it a critical focus in the field of molecular biology and ophthalmology.
