Analytical Data
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基因名
EphA7
- Application
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别名
EphA7；EHK3；HEK11；Ephrin type-A receptor 7
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8R381
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表达区间
580-994aa
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氨基酸序列
FMVFGFIIGRRHCGYSKADQEGDEELYFHCTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILDKMIRNPSSLKTPLGTCSRPISPLLDQSTPDFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA7 is a member of the Eph receptor family, which are the largest subfamily of receptor tyrosine kinases. These receptors play crucial roles in various biological processes, including cell adhesion, migration, and differentiation, making them vital in developmental biology and tissue homeostasis. Recent research has highlighted EphA7's involvement in the nervous system, particularly in neurogenesis and neuronal patterning. Additionally, EphA7 has been implicated in several pathological conditions, including cancer, where its expression levels can influence tumor progression and metastasis. The interest in EphA7 is further heightened by its potential as a therapeutic target, given that modulating its activity could provide new avenues for treating diseases associated with its dysregulation. However, the specific mechanisms underlying EphA7 signaling and its interactions with ephrins (its ligand family) are not fully understood, necessitating the development of recombinant EphA7 proteins for in-depth study. These recombinant proteins serve as critical tools in exploring the receptor's functional properties, binding affinities, and downstream signaling pathways. By providing a deeper understanding of EphA7's role in cellular communication and disease mechanisms, this research could pave the way for innovative therapeutic strategies and contribute significantly to the field of molecular biology and medicine.
