Analytical Data
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Gene name
EphA7
- Application
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Alternative Names
EphA7；EHK3；HEK11；Ephrin type-A receptor 7
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8R381
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Expression Region
580-994aa
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AA Sequence
FMVFGFIIGRRHCGYSKADQEGDEELYFHCTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILDKMIRNPSSLKTPLGTCSRPISPLLDQSTPDFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EphA7 is a member of the Eph receptor family, which are the largest subfamily of receptor tyrosine kinases. These receptors play crucial roles in various biological processes, including cell adhesion, migration, and differentiation, making them vital in developmental biology and tissue homeostasis. Recent research has highlighted EphA7's involvement in the nervous system, particularly in neurogenesis and neuronal patterning. Additionally, EphA7 has been implicated in several pathological conditions, including cancer, where its expression levels can influence tumor progression and metastasis. The interest in EphA7 is further heightened by its potential as a therapeutic target, given that modulating its activity could provide new avenues for treating diseases associated with its dysregulation. However, the specific mechanisms underlying EphA7 signaling and its interactions with ephrins (its ligand family) are not fully understood, necessitating the development of recombinant EphA7 proteins for in-depth study. These recombinant proteins serve as critical tools in exploring the receptor's functional properties, binding affinities, and downstream signaling pathways. By providing a deeper understanding of EphA7's role in cellular communication and disease mechanisms, this research could pave the way for innovative therapeutic strategies and contribute significantly to the field of molecular biology and medicine.
