Analytical Data
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基因名
COL6A2
- Application
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别名
COL6A2；Collagen alpha-2(VI) chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P12110
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表达区间
254-400aa
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氨基酸序列
IPGPSGPKGYRGQKGAKGNMGEPGEPGQKGRQGDPGIEGPIGFPGPKGVPGFKGEKGEFGADGRKGAPGLAGKNGTDGQKGKLGRIGPPGCKGDPGNRGPDGYPGEAGSPGERGDQGGKGDPGRPGRRGPPGEIGAKGSKGYQGNSG
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分子量
35.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL6A2, a member of the collagen VI family, plays a crucial role in the structural integrity and function of various tissues, particularly in the extracellular matrix (ECM). Mutations in the COL6A2 gene are associated with several connective tissue disorders, including Ullrich congenital muscular dystrophy and Bethlem myopathy, which are characterized by muscle weakness, joint contractures, and skin abnormalities. Researchers have focused on the recombinant expression of COL6A2 to better understand its biochemical properties and interactions within the ECM. Producing COL6A2 as a recombinant protein allows scientists to explore its role in cellular processes, including cell adhesion, proliferation, and differentiation. Furthermore, understanding the structure-function relationship of COL6A2 may reveal insights into the pathogenic mechanisms underlying COL6A2-related disorders. This research has potential therapeutic implications, as it could lead to the development of targeted treatments for connective tissue diseases, enhancing patient outcomes and quality of life. By elucidating the functional characteristics of COL6A2 through recombinant technology, researchers aim to advance the field of regenerative medicine and tissue engineering, paving the way for innovative strategies to repair or replace damaged tissues.
