Analytical Data
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基因名
COL12A1
- Application
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别名
COL12A1；COL12A1L；Collagen alpha-1(XII) chain
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99715
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表达区间
140-316aa
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氨基酸序列
DLVFLVDGSWSVGRNNFKYILDFIAALVSAFDIGEEKTRVGVVQYSSDTRTEFNLNQYYQRDELLAAIKKIPYKGGNTMTGDAIDYLVKNTFTESAGARVGFPKVAIIITDGKSQDEVEIPARELRNVGVEVFSLGIKAADAKELKQIASTPSLNHVFNVANFDAIVDIQNEIISQV
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分子量
23.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL12A1, a member of the collagen family, encodes a protein that plays a crucial role in the structural integrity of various tissues, particularly in the extracellular matrix. Research has shown that COL12A1 is involved in tissue repair and regeneration, making it a significant focus in studies related to fibrosis, wound healing, and musculoskeletal disorders. Its unique structure, characterized by the presence of multiple collagenous domains, allows it to interact with other matrix components, influencing cellular behaviors such as adhesion, migration, and differentiation. Abnormal expression or mutations in COL12A1 have been linked to various pathological conditions, including skeletal dysplasia and other connective tissue disorders. Consequently, the recombinant production of COL12A1 protein has garnered attention for potential therapeutic applications, including its use in tissue engineering and regenerative medicine. Understanding the functional characteristics and molecular mechanisms of COL12A1 through recombinant techniques could pave the way for novel treatments and enhance our knowledge of collagen-related diseases. This research aims to elucidate the biological roles of COL12A1 and explore its potential in clinical applications, thereby contributing to advancements in regenerative therapies and improving patient outcomes.
