Analytical Data
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Gene name
VNN2
- Application
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Alternative Names
VNN2；Pantetheine hydrolase VNN2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95498
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Expression Region
1-492aa
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AA Sequence
MVTSSFPISV AVFALITLQV GTQDSFIAAV YEHAVILPNK TETPVSQEDA LNLMNENIDI LETAIKQAAE QGARIIVTPE DALYGWKFTR ETVFPYLEDI PDPQVNWIPC QDPHRFGHTP VQARLSCLAK DNSIYVLANL GDKKPCNSRD STCPPNGYFQ YNTNVVYNTE GKLVARYHKY HLYSEPQFNV PEKPELVTFN TAFGRFGIFT CFDIFFYDPG VTLVKDFHVD TILFPTAWMN VLPLLTAIEF HSAWAMGMGV NLLVANTHHV SLNMTGSGIY APNGPKVYHY DMKTELGKLL LSEVDSHPLS SLAYPTAVNW NAYATTIKPF PVQKNTFRGF ISRDGFNFTE LFENAGNLTV CQKELCCHLS YRMLQKEENE VYVLGAFTGL HGRRRREYWQ VCTLLKCKTT NLTTCGRPVE TASTRFEMFS LSGTFGTEYV FPEVLLTEIH LSPGKFEVLK DGRLVNKNGS SGPILTVSLF GRWYTKDSLY SS
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Molecular Weight
55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
VNN2 (vanin-2) is a member of the vanin family of proteins, known for its role in the metabolism of pantetheine, a precursor to coenzyme A. Research into VNN2 has gained traction due to its involvement in several biological processes, including oxidative stress response, inflammation, and immune modulation. Recent studies have highlighted its potential implications in various diseases, such as diabetes, cardiovascular disorders, and neurological conditions, where altered oxidative pathways play a critical role. The interest in VNN2 is further fueled by findings that suggest it may serve as a biomarker for specific diseases or conditions, promoting the exploration of its therapeutic potential. As a result, the recombinant expression and purification of VNN2 have become a focal point for researchers aiming to elucidate its structure-function relationships and to develop potential therapeutic agents targeting VNN2-related pathways. Advances in recombinant protein technologies allow for the large-scale production and functional characterization of VNN2, paving the way for in-depth studies on its enzymatic functions and interactions with other biomolecules, thereby contributing to a better understanding of its biological relevance. This research can ultimately lead to innovative strategies for disease prevention and treatment, making VNN2 a compelling target for both basic research and clinical applications.
