Analytical Data
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Gene name
UBB
- Application
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Alternative Names
UBB；；Polyubiquitin-B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P0CG47
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Expression Region
1-76aa
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AA Sequence
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQL EDGRTLSDYNIQKESTLHLVLRLRGG
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBB (Ubiquitin B) recombinant proteins are crucial in the study of ubiquitin-related cellular processes, given their role in protein degradation, signaling, and cellular homeostasis. The ubiquitin-proteasome system (UPS) is a vital mechanism for modulating protein levels and regulating numerous cellular functions, including cell cycle progression, apoptosis, and stress responses. UBB, as an alternative form of ubiquitin, is involved in the covalent attachment of ubiquitin molecules to target proteins, which marks them for degradation or alters their functional properties. Research into UBB recombinant proteins focuses on understanding the dynamics of ubiquitination and deubiquitination processes, which are essential for maintaining healthy cellular environments. Furthermore, dysregulation of ubiquitin signaling pathways has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. By exploring UBB recombinant proteins, researchers aim to uncover potential therapeutic targets and develop strategies for modulating these pathways in disease contexts. The production of recombinant UBB proteins has also facilitated advanced techniques in proteomics and molecular biology, enabling scientists to dissect cellular mechanisms with greater precision. Overall, the study of UBB recombinant proteins is pivotal for elucidating the complexities of cellular regulation and developing innovative therapeutic approaches to combat diseases linked to ubiquitin pathway malfunctions.
