Analytical Data
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Gene name
PRKCDBP
- Application
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Alternative Names
Cavin 3; Cavin-3; CAVIN3; hSRBC; MGC20400; PRDBP_HUMAN; Prkcdbp; Protein kinase C delta binding protein; Protein kinase C delta-binding protein; Sdr related gene product that binds to c kinase; Serum deprivation response factor related gene product that binds to C kinase; Serum deprivation response factor-related gene product that binds to C-kinase; SRBC
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969G5
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Expression Region
1-261 aa
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AA Sequence
MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ GGLAGSVRRI QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV RRAAQVQRLE ANHGLLVARG KLHVLLFKEE GEVPASAFQK APEPLGPADQ SELGPEQLEA EVGESSDEEP VESRAQRLRR TGLQKVQSLR RALSGRKGPA APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT EEDPGRPGAA EEALLQMESV A
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Molecular Weight
27.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PRKCDBP (Protein Kinase C Delta Binding Protein) is a crucial adaptor protein that plays significant roles in various cellular processes, including signal transduction, cell survival, and apoptosis. Its interaction with Protein Kinase C (PKC) isoforms, particularly PKC delta, has garnered attention due to its implications in cancer progression, particularly in hematological malignancies. Research indicates that PRKCDBP may facilitate the localization and functional regulation of PKC delta, influencing downstream signaling pathways that promote tumorigenesis. Further investigation into the structural and functional characteristics of PRKCDBP can potentially unveil novel therapeutic targets in oncology, especially for cancers characterized by aberrant PKC signaling. As such, recombinant PRKCDBP proteins are being developed to elucidate its interactions and roles in cellular signaling networks, aiming to provide insights into its regulatory mechanisms and therapeutic potential. Understanding the dynamics of PRKCDBP in the context of cell signaling is vital, not only for cancer research but also for deciphering its involvement in other diseases where PKC signaling is disrupted. The study of this recombinant protein thus represents a promising frontier in the quest for targeted cancer therapies and improved clinical outcomes.
