Analytical Data
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基因名
PRKCB
- Application
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别名
KPCB_HUMAN; PKC Beta; PKC-B; PKC-beta; PKCB; Prkcb; PRKCB II; PRKCB2; Protein kinase C beta; Protein kinase C beta type
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P05771
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表达区间
2-671 aa
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氨基酸序列
ADPAAGPPP SEGEESTVRF ARKGALRQKN VHEVKNHKFT ARFFKQPTFC SHCTDFIWGF GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPASDDPRS KHKFKIHTYS SPTFCDHCGS LLYGLIHQGM KCDTCMMNVH KRCVMNVPSL CGTDHTERRG RIYIQAHIDR DVLIVLVRDA KNLVPMDPNG LSDPYVKLKL IPDPKSESKQ KTKTIKCSLN PEWNETFRFQ LKESDKDRRL SVEIWDWDLT SRNDFMGSLS FGISELQKAS VDGWFKLLSQ EEGEYFNVPV PPEGSEANEE LRQKFERAKI SQGTKVPEEK TTNTVSKFDN NGNRDRMKLT DFNFLMVLGK GSFGKVMLSE RKGTDELYAV KILKKDVVIQ DDDVECTMVE KRVLALPGKP PFLTQLHSCF QTMDRLYFVM EYVNGGDLMY HIQQVGRFKE PHAVFYAAEI AIGLFFLQSK GIIYRDLKLD NVMLDSEGHI KIADFGMCKE NIWDGVTTKT FCGTPDYIAP EIIAYQPYGK SVDWWAFGVL LYEMLAGQAP FEGEDEDELF QSIMEHNVAY PKSMSKEAVA ICKGLMTKHP GKRLGCGPEG ERDIKEHAFF RYIDWEKLER KEIQPPYKPK ARDKRDTSNF DKEFTRQPVE LTPTDKLFIM NLDQNEFAGF SYTNPEFVIN V
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分子量
76.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRKCB, or protein kinase C beta, is a member of the protein kinase C (PKC) family, which plays a crucial role in various cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of PRKCB has been associated with several diseases, including cancer, cardiovascular disorders, and neurological conditions. The study of PRKCB recombinant proteins is significant for several reasons. First, understanding its structure and function can shed light on the molecular mechanisms of diseases where PRKCB is implicated. Second, the use of recombinant PRKCB can facilitate the development of targeted therapies, allowing for the design of inhibitors that can modulate its activity and potentially reverse pathological states. Furthermore, PRKCB's role in signaling pathways makes it an attractive target for drug development, as small molecules or biologics that can selectively influence its activity might lead to novel treatment strategies. Researchers are utilizing advanced techniques, such as X-ray crystallography and NMR spectroscopy, to elucidate the structure-function relationships of PRKCB. Additionally, the expression and purification of recombinant PRKCB enable comprehensive biochemical and pharmacological studies, providing insights into how it interacts with other cellular components. Overall, the research surrounding PRKCB recombinant proteins is vital for advancing our understanding of cellular signaling and developing new therapeutic interventions for diseases linked to PRKCB dysregulation.
