Analytical Data
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Gene name
Ascl2
- Application
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Alternative Names
Ascl2；BHLHA45；HASH2；Achaete-scute homolog 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99929
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Expression Region
1-193aa
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AA Sequence
MDGGTLPRSA PPAPPVPVGC AARRRPASPE LLRCSRRRRP ATAETGGGAA AVARRNERER NRVKLVNLGF QALRQHVPHG GASKKLSKVE TLRSAVEYIR ALQRLLAEHD AVRNALAGGL RPQAVRPSAP RGPPGTTPVA ASPSRASSSP GRGGSSEPGS PRSAYSSDDS GCEGALSPAE RELLDFSSWL GGY
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Molecular Weight
20.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Ascl2, also known as Achaete-Scute Complex Homolog 2, is a transcription factor that plays a crucial role in cellular differentiation and development, especially in the context of neurogenesis and stem cell biology. Its regulation of various target genes is critical for the maintenance of pluripotency and the promotion of lineage specification in embryonic stem cells. Recent studies have highlighted Ascl2's involvement in the development of the central nervous system and its potential role in cancer biology. Research on recombinant Ascl2 protein has gained traction as scientists seek to elucidate its structure-function relationship, understand its molecular mechanisms, and identify its interacting partners. The production of recombinant Ascl2 allows for detailed in vitro studies, enabling researchers to investigate its functionality in cellular contexts and to explore its potential as a therapeutic target. Additionally, understanding Ascl2's role in reprogramming and differentiation could have significant implications for regenerative medicine and the treatment of neurodegenerative diseases. Thus, ongoing research into Ascl2 recombinant protein contributes valuable insights into developmental biology and opens new avenues for targeted therapeutic strategies.
