Analytical Data
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Gene name
PRDM11
- Application
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Alternative Names
PRDM11; PFM8; PR domain-containing protein 11; EC 2.1.1.-
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQV5
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Expression Region
1-511 aa
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AA Sequence
MLKMAEPIAS LMIVECRACL RCSPLFLYQR EKDRMTENMK ECLAQTNAAV GDMVTVVKTE VCSPLRDQEY GQPCSRRPDS SAMEVEPKKL KGKRDLIVPK SFQQVDFWFC ESCQEYFVDE CPNHGPPVFV SDTPVPVGIP DRAALTIPQG MEVVKDTSGE SDVRCVNEVI PKGHIFGPYE GQISTQDKSA GFFSWLIVDK NNRYKSIDGS DETKANWMRY VVISREEREQ NLLAFQHSER IYFRACRDIR PGEWLRVWYS EDYMKRLHSM SQETIHRNLA RGEKRLQREK SEQVLDNPED LRGPIHLSVL RQGKSPYKRG FDEGDVHPQA KKKKIDLIFK DVLEASLESA KVEAHQLALS TSLVIRKVPK YQDDAYSQCA TTMTHGVQNI GQTQGEGDWK VPQGVSKEPG QLEDEEEEPS SFKADSPAEA SLASDPHELP TTSFCPNCIR LKKKVRELQA ELDMLKSGKL PEPPVLPPQV LELPEFSDPA GKLVWMRLLS EGRVRSGLCG G
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Molecular Weight
57.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRDM11 is a member of the PR-domain containing protein family, which plays a crucial role in gene regulation and epigenetic modification. It has been associated with various biological processes, including development and differentiation. Recent studies have highlighted its potential implications in cancer biology, particularly due to its involvement in cell proliferation and survival pathways. Given the complex regulatory mechanisms that PRDM11 is part of, understanding its molecular functions and interactions is vital. Researchers are particularly interested in its role as a transcription factor and its influence on chromatin dynamics. The recombinant expression of PRDM11 allows for the detailed study of its functional roles in cellular contexts, enabling the exploration of its interactions with other molecular partners. By using techniques such as protein-protein interaction assays and chromatin immunoprecipitation, scientists aim to elucidate the pathways that PRDM11 modulates and its potential as a therapeutic target. The study of recombinant PRDM11 not only contributes to a deeper understanding of its biological significance but also opens avenues for developing novel strategies to combat diseases linked to its dysregulation, particularly in oncological settings.
