Analytical Data
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Gene name
HOXB4
- Application
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Alternative Names
HOXB4；HOX2F；Homeobox Protein Hox-B4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P17483
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Expression Region
1-251aa
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AA Sequence
MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYAACRDPGPPPPPPPPPPPPPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGAAGSAGGPPGRPNGGPRAL
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Molecular Weight
29.6kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HOXB4 is a crucial transcription factor belonging to the homeobox gene family, which plays a pivotal role in embryonic development and cell differentiation. Its expression is primarily associated with hematopoiesis, the process by which blood cells are formed, making it of significant interest in the fields of developmental biology and regenerative medicine. Research has shown that HOXB4 can enhance the expansion of hematopoietic stem cells (HSCs) and their differentiation into various blood lineages, suggesting its potential therapeutic applications in treating blood disorders such as leukemia, anemia, and other hematologic diseases. The ability of HOXB4 to regulate the expression of downstream target genes involved in cell proliferation and survival positions it as a key player in not only normal hematopoiesis but also in pathological conditions. Furthermore, the development of recombinant HOXB4 protein has opened new avenues for investigating the molecular mechanisms underlying its function and for exploring its application in stem cell therapy and gene editing. Understanding the detailed interactions and pathways influenced by HOXB4 is essential for harnessing its properties in clinical settings, thereby advancing treatment strategies for hematological diseases and improving patient outcomes. As research continues to uncover the complexities of HOXB4's role in stem cell biology, it highlights the importance of further studies to optimize its utility in regenerative medicine.
