Analytical Data
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基因名
PRAM-1
- Application
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别名
PML RAR; PML RARA regulated adaptor molecule 1; PML RARA target gene encoding an Adaptor Molecule 1; PML-RARA-regulated adapter molecule 1; PRAM 1; PRAM; PRAM-1; PRAM_HUMAN; PRAM1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96QH2
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表达区间
1-718 aa
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氨基酸序列
MAHHLPAAME SHQDFRSIKA KFQASQPEPS DLPKKPPKPE FGKLKKFSQP ELSEHPKKAP LPEFGAVSLK PPQPQFTDLP KKPPPPEVTD LPKKPPPPEV TDLPKKPPPP EVTDLPKKPP PPEVTDLPKK PPPPEVTDLP KKPPPPEVTD LPKKPPPPEV TDLPKKPSKL ELSDLSKKFP QLGATPFPRK PLQPEVGEAP LKASLPEPGA PARKPLQPDE LSHPARPPSE PKSGAFPRKL WQPEAGEATP RSPQPELSTF PKKPAQPEFN VYPKKPPQPQ VGGLPKKSVP QPEFSEAAQT PLWKPQSSEP KRDSSAFPKK ASQPPLSDFP KKPPQPELGD LTRTSSEPEV SVLPKRPRPA EFKALSKKPP QPELGGLPRT SSEPEFNSLP RKLLQPERRG PPRKFSQPEP SAVLKRHPQP EFFGDLPRKP PLPSSASESS LPAAVAGFSS RHPLSPGFGA AGTPRWRSGG LVHSGGARPG LRPSHPPRRR PLPPASSLGH PPAKPPLPPG PVDMQSFRRP SAASIDLRRT RSAAGLHFQD RQPEDIPQVP DEIYELYDDV EPRDDSSPSP KGRDEAPSVQ QAARRPPQDP ALRKEKDPQP QQLPPMDPKL LKQLRKAEKA EREFRKKFKF EGEIVVHTKM MIDPNAKTRR GGGKHLGIRR GEILEVIEFT SNEEMLCRDP KGKYGYVPRT ALLPLETEVY DDVDFCDPLE NQPLPLGR
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分子量
73.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PRAM-1, or the Phosphorylation Regulating Activator of Monocyte 1, is a key protein involved in various cellular processes, including inflammation, immune response, and cell signaling. Research into PRAM-1 has gained traction due to its potential role in modulating immune functions, particularly in the context of autoimmune diseases and chronic inflammatory conditions. As a member of the tumor necrosis factor receptor (TNFR) superfamily, PRAM-1 is believed to interact with various signaling pathways, influencing the activation and differentiation of immune cells. Studies have shown that the dysregulation of PRAM-1 expression or function can lead to altered inflammatory responses, making it a target of interest for therapeutic interventions. Understanding the structure and dynamics of PRAM-1, particularly through the study of recombinant forms of the protein, offers insights into its functional mechanisms and potential roles in disease. Researchers have been exploring PRAM-1's association with disease markers, cellular signaling cascades, and its interactions with other proteins to uncover its comprehensive biological functions. This research is crucial not only for elucidating the fundamental biology of PRAM-1 but also for developing novel treatments aimed at modulating immune responses in various pathological conditions. Overall, PRAM-1 represents a promising subject for ongoing research in the fields of immunology and molecular medicine.
