Analytical Data
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基因名
HCFC2
- Application
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别名
HCFC2；Host cell factor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5Z7
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表达区间
1-792aa
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氨基酸序列
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR WLQGNNKKAP LN
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HCFC2, or Human Chymotrypsinogen C2, is a significant protein involved in the digestion of proteins in the human body. It is a member of the serine protease family, which plays a crucial role in various physiological processes. Research on HCFC2 is primarily driven by its potential implications in understanding digestive disorders, pancreatic function, and the development of targeted therapies. The protein is synthesized in the pancreas as an inactive precursor and is activated in the gastrointestinal tract, highlighting its importance in maintaining proper digestive functions. Additionally, abnormalities in HCFC2 expression or activation have been linked to various pathologies, including pancreatitis and pancreatic cancer. As such, studying HCFC2 can provide insights into not only its enzymatic mechanisms but also its role in disease pathogenesis. Recent developments in structural biology, including X-ray crystallography and nuclear magnetic resonance (NMR), have enabled scientists to elucidate its three-dimensional structure and substrate specificity. This knowledge can aid in the design of synthetic inhibitors that can potentially be used for therapeutic interventions. Furthermore, HCFC2 serves as a model for understanding the broader family of serine proteases, making it a valuable target for fundamental research in biochemistry and molecular biology. Overall, the multifaceted role of HCFC2 in digestion and its association with various diseases underscore the importance of ongoing research to fully elucidate its functions and therapeutic potential.
