Analytical Data
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基因名
ABCC1
- Application
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别名
ABCC1；MRP；MRP1；Multidrug resistance-associated Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P33527
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表达区间
1248-1531aa
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氨基酸序列
VRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMA kDaGLV
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分子量
35.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ABCC1, also known as Multi-Drug Resistance Protein 1 (MRP1), is a member of the ATP-binding cassette (ABC) transporter family, which is implicated in the cellular efflux of a wide range of substrates, including chemotherapeutic drugs, endogenous metabolites, and signaling molecules. The protein plays a significant role in drug resistance, as its overexpression in cancer cells can lead to decreased intracellular concentrations of anticancer agents, thereby reducing their efficacy. Understanding the molecular mechanisms governing ABCC1 function and regulation is crucial for developing strategies to overcome drug resistance in cancer therapies. The study of recombinant ABCC1 protein allows researchers to investigate its structural properties, substrate specificity, and interaction mechanisms in a controlled environment. Furthermore, the availability of functional recombinant protein can facilitate high-throughput screening of potential inhibitors, aiding in the discovery of compounds that may reverse MRP1-mediated drug resistance. Thus, research on recombinant ABCC1 protein is fundamental for elucidating its role in pharmacology and developing innovative therapeutic approaches to enhance the effectiveness of existing cancer treatments.
