Analytical Data
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Gene name
C12orf41
- Application
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Alternative Names
chromosome 12 open reading frame 41; hypothetical Protein LOC54934 ; KANL2_HUMAN; KANSL2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H9L4
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Expression Region
1-492aa
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AA Sequence
MNRIRIHVLP TNRGRITPVP RSQEPLSCAF THRPCSHPRL EGQEFCIKHI LEDKNAPFKQ CSYISTKNGK RCPNAAPKPE KKDGVSFCAE HVRRNALALH AQMKKTNPGP VGETLLCQLS SYAKTELGSQ TPESSRSEAS RILDEDSWSD GEQEPITVDQ TWRGDPDSEA DSIDSDQEDP LKHAGVYTAE EVALIMREKL IRLQSLYIDQ FKRLQHLLKE KKRRYLHNRK VEHEALGSSL LTGPEGLLAK ERENLKRLKC LRRYRQRYGV EALLHRQLKE RRMLATDGAA QQAHTTRSSQ RCLAFVDDVR CSNQSLPMTR HCLTHICQDT NQVLFKCCQG SEEVPCNKPV PVSLSEDPCC PLHFQLPPQM YKPEQVLSVP DDLEAGPMDL YLSAAELQPT ESLPLEFSDD LDVVGDGMQC PPSPLLFDPS LTLEDHLVKE IAEDPVDILG QMQMAGDGCR SQGSRNSEKA SAPLSQSGLA TANGKPEPTS IS
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Molecular Weight
55 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
C12orf41, also known as cilium- and doublecortin-associated protein, has garnered significant attention in recent years due to its potential role in cellular processes related to ciliogenesis and neurodevelopment. This protein is located on chromosome 12 and is thought to be involved in cytoskeletal dynamics and intracellular transport, essential functions for the formation and maintenance of cilia, which are critical for cell signaling and sensory functions. Mutations in C12orf41 have been associated with a range of neurodevelopmental disorders, underscoring its importance in brain development and function. The generation of recombinant C12orf41 protein provides a valuable tool for investigating its structure, function, and interactions at the molecular level. Through the production of this protein in model systems, researchers aim to elucidate its role in the assembly and functioning of cilia and its implications in neuronal health and disease. Understanding the mechanisms by which C12orf41 operates could pave the way for developing therapeutic strategies for conditions linked to its dysfunction, contributing to broader insights into the biology of the cilia and their impact on human health.
