Analytical Data
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Gene name
CXCL16
- Application
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Alternative Names
CXCL16；SCYB16；C-X-C motif chemokine 16
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Species
Mouse
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8BSU2
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Expression Region
27-114aa
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AA Sequence
NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP
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Molecular Weight
28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CXCL16, a chemokine belonging to the CXC family of chemokines, plays a significant role in the immune response and inflammation. It is primarily expressed by various cell types, including dendritic cells, macrophages, and endothelial cells, and is involved in the recruitment of immune cells, particularly T cells and dendritic cells, to sites of inflammation and infection. The protein exerts its biological effects through binding to its receptor, CXCR6, which is expressed on several immune cell types, thereby facilitating immune surveillance and modulating the adaptive immunity. Given its crucial functions, CXCL16 has been associated with various pathological conditions, including cancer, autoimmune diseases, and chronic inflammatory disorders. Thus, generating recombinant CXCL16 protein has become essential for studying its functional roles in these contexts. Researchers aim to produce high-purity recombinant CXCL16 to explore its chemotactic properties, receptor interactions, and potential therapeutic applications, such as targeted immunotherapy and vaccine development. Understanding the precise mechanisms by which CXCL16 influences immune responses may provide insights into developing novel treatments for diseases characterized by immune dysregulation. This protein's study can deepen our understanding of immune cell trafficking and has significant implications for devising strategies to enhance anti-tumor immunity or attenuate harmful inflammation in autoimmune conditions.
