Analytical Data
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Gene name
PPP2R5C
- Application
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Alternative Names
2A5G_HUMAN; B' alpha regulatory subunit; B56G; KIAA0044 ; MGC23064 ; PP2A B subunit B' gamma isoform; PP2A B subunit B56 gamma isoform; PP2A B subunit isoform B' gamma; PP2A B subunit isoform B''-gamma; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; PP2A B subunit PR61 gamma isoform; PP2A B subunit R5 gamma isoform; Ppp2r5c; PR61G ; Protein phosphatase 2 regulatory subunit B (B56) gamma isoform; Protein phosphatase 2 regulatory subunit B' gamma; Protein phosphatase 2; regulatory subunit B'; gamma isoform; Renal carcinoma antigen NY REN 29; Renal carcinoma antigen NY-REN-29; Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform ; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13362
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Expression Region
1-524 aa
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AA Sequence
MLTCNKAGSR MVVDAANSNG PFQPVVLLHI RDVPPADQEK LFIQKLRQCC VLFDFVSDPL SDLKWKEVKR AALSEMVEYI THNRNVITEP IYPEVVHMFA VNMFRTLPPS SNPTGAEFDP EEDEPTLEAA WPHLQLVYEF FLRFLESPDF QPNIAKKYID QKFVLQLLEL FDSEDPRERD FLKTTLHRIY GKFLGLRAYI RKQINNIFYR FIYETEHHNG IAELLEILGS IINGFALPLK EEHKIFLLKV LLPLHKVKSL SVYHPQLAYC VVQFLEKDST LTEPVVMALL KYWPKTHSPK EVMFLNELEE ILDVIEPSEF VKIMEPLFRQ LAKCVSSPHF QVAERALYYW NNEYIMSLIS DNAAKILPIM FPSLYRNSKT HWNKTIHGLI YNALKLFMEM NQKLFDDCTQ QFKAEKLKEK LKMKEREEAW VKIENLAKAN PQYTVYSQAS TMSIPVAMET DGPLFEDVQM LRKTVKDEAH QAQKDPKKDR PLARRKSELP QDPHTKKALE AHCRADELAS QDGR
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Molecular Weight
61.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP2R5C, a member of the Protein Phosphatase 2A (PP2A) regulatory subunit family, plays a critical role in orchestrating various cellular processes, including cell growth, division, and apoptosis. The significance of PPP2R5C arises from its ability to modulate PP2A activity, which is fundamental in regulating signaling pathways that control cell proliferation and tumor suppression. Dysregulation of PP2A, often linked to various cancers, highlights the necessity of understanding PPP2R5C function and its interactions within the PP2A holocomplex. Research has shown that the specific regulatory role of PPP2R5C can influence not only basic cellular functions but also responses to external stimuli such as stress and growth factors. Additionally, as a potential biomarker for certain cancers, the study of PPP2R5C-recombinant proteins offers valuable insights into therapeutic strategies aimed at restoring normal PP2A function and inhibiting tumor progression. Further investigations into its molecular mechanisms and downstream targets could pave the way for novel interventions in cancer treatment, enhancing the understanding of its relevance in both normal physiology and pathological conditions. These insights exemplify the importance of PPP2R5C in cancer biology and underscore the need for extensive research into its biochemical pathways and potential therapeutic applications, making it a vital focus for future studies in cellular signaling and oncology.
