Analytical Data
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Gene name
MAP1LC3A
- Application
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Alternative Names
MAP1LC3A；APG7L；；Ubiquitin-like modifier-activating enzyme ATG7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H492
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Expression Region
1-120aa
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AA Sequence
MPSDRPFKQR RSFADRCKEV QQIRDQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM SELVKIIRRR LQLNPTQAFF LLVNQHSMVSVSTPIADIYE QEKDEDGFLY MVYASQETFG LEHHHHHH
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAP1LC3A, a member of the microtubule-associated protein family, is a crucial protein involved in the process of autophagy, a cellular mechanism for degrading and recycling cellular components. The importance of MAP1LC3A in autophagy is underscored by its role in the formation of autophagosomes, the structures that encapsulate cellular debris for degradation. Research has highlighted MAP1LC3A’s involvement in various physiological and pathological processes, including neurodegenerative diseases, cancer, and infections. Given its pivotal role in cellular homeostasis and stress responses, the study of MAP1LC3A and its recombinant forms has garnered significant attention. By generating recombinant MAP1LC3A proteins, researchers aim to further elucidate the mechanisms underlying autophagy and its regulation. This includes investigating how MAP1LC3A interacts with other cellular components and its potential as a therapeutic target. In particular, understanding the dynamics of MAP1LC3A in different cellular contexts may pave the way for developing novel strategies to modulate autophagy in disease. Overall, the investigation of MAP1LC3A through recombinant protein studies serves to deepen our understanding of cellular processes and holds promise for advancing therapeutic approaches in various diseases characterized by dysregulated autophagy.
