Analytical Data
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基因名
IFNAR2
- Application
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别名
IFNAR2；IFNABR；Interferon alpha/beta receptor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48551
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表达区间
27-243aa
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氨基酸序列
ISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKP EDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNF WLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEG IVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLK CTLLPPGQESESAESAKVDHHHHHH
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分子量
26 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interferon-alpha receptor 2 (IFNAR2) is a crucial protein that plays a significant role in the immune response mediated by type I interferons, which are vital for combating viral infections and modulating the immune system. It is one of the two subunits of the type I interferon receptor, with the other being IFNAR1. The binding of type I interferon to this receptor initiates a cascade of signaling events that lead to the expression of various antiviral proteins and immune-modulatory factors, thereby enhancing the host's defense mechanisms. Research into IFNAR2 has gained prominence due to its implications in viral pathogenesis, autoimmune diseases, and potential therapeutic applications. Understanding the structural and functional dynamics of IFNAR2 can provide insights into its role in these processes. Moreover, recombinant IFNAR2 proteins are valuable tools for investigating receptor interactions, signaling pathways, and the development of antiviral drugs. Studying the mechanisms by which IFNAR2 mediates its effects can lead to advancements in vaccine development and targeted therapies for diseases related to dysregulated interferon responses. Additionally, the exploration of IFNAR2 interactions with other cellular proteins may uncover novel therapeutic targets for enhancing antiviral immune responses or mitigating autoimmune disorders. Overall, the study of IFNAR2 and its recombinant forms represents a promising avenue for research in immunology and virology, with the potential to inform future clinical strategies.
