Analytical Data
-
Gene name
MT-ND1
- Application
-
Alternative Names
MT-ND1；MTND1；NADH1；ND1；NADH-ubiquinone oxidoreductase chain 1
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P03886
-
Expression Region
1-318aa
-
AA Sequence
MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSGWASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTTIFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLALLMWYVSMPITISSIPPQT
-
Molecular Weight
35.6 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MT-ND1, a crucial component of the mitochondrial respiratory chain, encodes the NADH dehydrogenase subunit 1, which plays a pivotal role in cellular energy production through oxidative phosphorylation. Its dysfunction is linked to various mitochondrial diseases, neurodegenerative disorders, and aging-related pathologies, highlighting the importance of understanding its structure and function. Research on MT-ND1 recombinant proteins has gained momentum as scientists aim to elucidate the mechanisms underlying mitochondrial dysfunction. The production of these recombinant proteins allows for in vitro studies that provide insights into the assembly, regulation, and interactions of mitochondrial complexes. Additionally, studying MT-ND1 in a controlled laboratory environment enables the identification of potential therapeutic targets and the development of treatments for mitochondrial diseases. The advancement of techniques such as CRISPR gene editing and high-resolution cryo-electron microscopy has further propelled research in this field, allowing for detailed investigations of MT-ND1's impact on mitochondrial health and overall cellular function. Understanding the dynamics of MT-ND1 not only sheds light on fundamental biological processes but also paves the way for innovative therapeutic strategies to combat mitochondrial dysfunction and associated diseases.
