Analytical Data
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基因名
NCR3LG1
- Application
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别名
NCR3LG1；B7H6；Natural cytotoxicity triggering receptor 3 ligand 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q68D85
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表达区间
1-262aa
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氨基酸序列
MTWRAAASTC AALLILLWAL TTEGDLKVEM MAGGTQITPL NDNVTIFCNI FYSQPLNITS MGITWFWKSL TFDKEVKVFE FFGDHQEAFR PGAIVSPWRL KSGDASLRLP GIQLEEAGEY RCEVVVTPLK AQGTVQLEVV ASPASRLLLD QVGMKENEDK YMCESSGFYP EAINITWEKQ TQKFPHPIEI SEDVITGPTI KNMDGTFNVT SCLKLNSSQE DPGTVYQCVV RHASLHTPLR SNFTLTAARH SLSETEKTDN FS
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分子量
28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NCR3LG1, a member of the natural cytotoxicity receptor (NCR) family, plays a crucial role in the immune response, particularly in the activation of natural killer (NK) cells. Identified for its involvement in recognizing and eliminating tumor cells, NCR3LG1 is being extensively studied for its potential therapeutic applications in cancer immunotherapy. The receptor is expressed on the surface of NK cells and is instrumental in mediating their cytotoxic functions. Research has shown that NCR3LG1 can enhance NK cell activation and promote the secretion of cytokines, which are vital for mounting an effective immune response against malignancies. Moreover, the interaction between NCR3LG1 and its ligands on target cells contributes to the regulation of tumor surveillance mechanisms. Understanding the molecular mechanisms underlying NCR3LG1's function could lead to the development of novel strategies to harness NK cell activity for cancer treatment. Furthermore, as researchers explore the structure-function relationship of NCR3LG1 through recombinant protein technology, the generation of purified NCR3LG1 proteins provides valuable tools for functional assays and therapeutic development, offering promising avenues for enhancing cancer therapy efficacy. The ongoing investigation into NCR3LG1 not only sheds light on NK cell biology but also represents a significant step towards advancing immunotherapeutic approaches to improve patient outcomes in cancer treatment.
