Analytical Data
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Gene name
CD320
- Application
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Alternative Names
CD320；8D6A；CD320 antigen
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPF0
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Expression Region
36-231aa
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AA Sequence
SPLSTPTSAQAAGPSSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSD EEECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAG ELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILPEGDATTMGPPV TLESVTSLRNATTMGPPVTLESVPSVGNATSSSAGDQSGSPTAYGVVDDI EGRMDEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVT CVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLH QDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTK NQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKL TVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CD320, also known as the receptor for vitamin B12, is a membrane protein that plays a crucial role in the uptake of vitamin B12 in various cell types, particularly in the gut and immune system. Research has shown that CD320 is pivotal for maintaining cellular metabolism and promoting proper immune function, as vitamin B12 is essential for DNA synthesis, red blood cell formation, and neurological function. Dysregulation of CD320 has been linked to several health conditions, including anemia, neurodegenerative diseases, and some cancers. Recent studies have focused on the characterization of recombinant CD320 proteins to better understand its structure-function relationship, which could reveal insights into its mechanistic role in vitamin B12 transport. These recombinant proteins can be utilized in various applications, including therapeutic agents aimed at correcting vitamin B12 deficiency and targeted immunotherapies. Moreover, studying CD320's interaction with its ligand, intrinsic factor, can provide valuable information for the development of novel diagnostics and treatments for related disorders. Through advancing our understanding of CD320's biology and potential clinical implications, this research contributes to a broader comprehension of micronutrient uptake and its significance in human health.
