Analytical Data
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Gene name
C10orf126
- Application
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Alternative Names
C10orf126Putative uncharacterized Protein C10orf126
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N4M7
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Expression Region
1-172aa
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AA Sequence
MNHCIQFSPQ SLQRWLILPC YDLKLPIWAN TTEFCPHGPR RASQDPQLLA WLPDQSLEVS LELYDWNSMT FTLFLETVEP VAVESEGSGI FSFVWQQLIF PAEARWCFSW AQDCGLDGSF PGSAHTEPFG KAAAGQGSVA GKEAKKAGPG FHRQLLYLQF QKRCLFNYPE LL
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Molecular Weight
19.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
C10orf126, also known as ALPS (Autoimmune Lymphoproliferative Syndrome) gene, encodes a protein implicated in the regulation of immune responses and lymphocyte homeostasis. Research on C10orf126 has gained attention due to its association with autoimmune disorders and lymphoproliferative diseases. The protein's role in controlling lymphocyte apoptosis and differentiation suggests that dysregulation could contribute to the pathogenesis of these diseases. Recent studies have explored the functional domains of the C10orf126 protein, identifying critical regions involved in its interactions with other signaling pathways, such as those mediated by CD27 and Fas receptor signaling. This research is essential for understanding how C10orf126 mutations may lead to aberrant immune responses, revealing potential therapeutic targets for treating autoimmune diseases. Furthermore, the production of recombinant C10orf126 protein allows for in-depth functional analyses in vitro, providing insights into its biological roles and how it may be manipulated for therapeutic benefit. Understanding the molecular mechanisms underlying its function will advance the development of novel strategies for managing autoimmune conditions and enhancing immune regulation.
