Analytical Data
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Gene name
NRROS
- Application
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Alternative Names
NRROS；LRRC33；Transforming growth factor beta activator LRRC33
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86YC3
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Expression Region
19-650aa
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AA Sequence
WRNRSGTATAASQGVCKLVGGAADCRGQSLASVPSSLPPHARMLTLDANPLKTLWNHSLQPYPLLESLSLHSCHLERISRGAFQEQGHLRSLVLGDNCLSENYEETAAALHALPGLRRLDLSGNALTEDMAALMLQNLSSLRSVSLAGNTIMRLDDSVFEGLERLRELDLQRNYIFEIEGGAFDGLAELRHLNLAFNNLPCIVDFGLTRLRVLNVSYNVLEWFLATGGEAAFELETLDLSHNQLLFFPLLPQYSKLRTLLLRDNNMGFYRDLYNTSSPREMVAQFLLVDGNVTNITTVSLWEEFSSSDLADLRFLDMSQNQFQYLPDGFLRKMPSLSHLNLHQNCLMTLHIREHEPPGALTELDLSHNQLSELHLAPGLASCLGSLRLFNLSSNQLLGVPPGLFANARNITTLDMSHNQISLCPLPAASDRVGPPSCVDFRNMASLRSLSLEGCGLGALPDCPFQGTSLTYLDLSSNWGVLNGSLAPLQDVAPMLQVLSLRNMGLHSSFMALDFSGFGNLRDLDLSGNCLTTFPRFGGSLALETLDLRRNSLTALPQKAVSEQLSRGLRTIYLSQNPYDCCGVDGWGALQHGQTVADWAMVTCNLSSKIIRVTELPGGVPRDCKWERLDLGL
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Molecular Weight
74.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NRROS (Negative Regulator of ROS) is an important protein that has garnered significant interest in recent years due to its role in regulating reactive oxygen species (ROS) levels within cells. ROS are byproducts of cellular metabolism and can serve as signaling molecules; however, excessive ROS accumulation can lead to oxidative stress, resulting in cellular damage and contributing to various diseases, including neurodegeneration, cancer, and cardiovascular disorders. NRROS functions as a negative regulator, modulating the balance of ROS and thus playing a crucial role in maintaining cellular homeostasis. Recent studies have highlighted the potential therapeutic implications of NRROS, suggesting that its manipulation could offer novel strategies for treating diseases associated with oxidative stress. The recombinant expression of NRROS provides a valuable tool for investigating its functional mechanisms and interactions within biological systems. Understanding the structure and activity of NRROS through recombinant protein studies can reveal insights into its regulatory pathways and therapeutic potential, making it a promising target for drug development and intervention strategies aimed at mitigating the effects of oxidative stress-related diseases. Additionally, exploring the role of NRROS in different biological contexts could uncover its broader implications in health and disease, emphasizing the need for further research in this area.
