Analytical Data
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基因名
PODXL2
- Application
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别名
PODXL2; UNQ1861/PRO3742; Podocalyxin-like protein 2; Endoglycan
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NZ53
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表达区间
1-605 aa
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氨基酸序列
MGRLLRAARLPPLLSPLLLLLVGGAFLGACVAGSDEPGPEGLTSTSLLDLLLPTGLEPLDSEEPSETMGLGAGLGAPGSGFPSEENEESRILQPPQYFWEEEEELNDSSLDLGPTADYVFPDLTEKAGSIEDTSQAQELPNLPSPLPKMNLVEPPWHMPPREEEEEEEEEEEREKEEVEKQEEEEEEELLPVNGSQEEAKPQVRDFSLTSSSQTPGATKSRHEDSGDQASSGVEVESSMGPSLLLPSVTPTTVTPGDQDSTSQEAEATVLPAAGLGVEFEAPQEASEEATAGAAGLSGQHEEVPALPSFPQTTAPSGAEHPDEDPLGSRTSASSPLAPGDMELTPSSATLGQEDLNQQLLEGQAAEAQSRIPWDSTQVICKDWSNLAGKNYIILNMTENIDCEVFRQHRGPQLLALVEEVLPRHGSGHHGAWHISLSKPSEKEQHLLMTLVGEQGVVPTQDVLSMLGDIRRSLEEIGIQNYSTTSSCQARASQVRSDYGTLFVVLVVIGAICIIIIALGLLYNCWQRRLPKLKHVSHGEELRFVENGCHDNPTLDVASDSQSEMQEKHPSLNGGGALNGPGSWGALMGGKRDPEDSDVFEEDTHL
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分子量
91.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PODXL2, a member of the podocalyxin glycoprotein family, has emerged as a significant focus in the field of biomedical research due to its potential roles in various physiological and pathological processes. Initially identified in the context of kidney development, PODXL2 has been shown to play crucial roles in cellular signaling, adhesion, and migration, making it relevant in the study of cancer metastasis and progression. Overexpression of PODXL2 has been associated with several types of cancers, including breast and colorectal cancers, where it is implicated in promoting tumor growth and escape from immune surveillance. Researchers have increasingly been interested in characterizing the structural and functional properties of PODXL2, particularly its glycosylation patterns, which may influence its interactions with other cell surface proteins and the extracellular matrix. The recombinant expression of PODXL2 allows scientists to obtain pure, functional protein for advanced studies, including biochemical assays, structural analyses, and therapeutic applications. By elucidating the molecular mechanisms underlying PODXL2’s function, researchers hope to develop targeted strategies for cancer treatment, as well as novel biomarkers for disease prognosis. Additionally, the study of PODXL2 is shedding light on its potential roles in other diseases characterized by abnormal cellular behaviors, thus broadening its relevance in medical research.
