Analytical Data
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基因名
NLGN1
- Application
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别名
NLGN1；KIAA1070；Neuroligin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N2Q7-2
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表达区间
1-677aa
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氨基酸序列
MALPRCTWPN YVWRAVMACL VHRGLGAPLT LCMLGCLLQA GHVLSQKLDD VDPLVATNFG KIRGIKKELN NEILGPVIQF LGVPYAAPPT GERRFQPPEP PSPWSDIRNA TQFAPVCPQN IIDGRLPEVM LPVWFTNNLD VVSSYVQDQS EDCLYLNIYV PTEDDIRDSG GPKPVMVYIH GGSYMEGTGN LYDGSVLASY GNVIVITVNY RLGVLGFLST GDQAAKGNYG LLDLIQALRW TSENIGFFGG DPLRITVFGS GAGGSCVNLL TLSHYSEGNR WSNSTKGLFQ RAIAQSGTAL SSWAVSFQPA KYARMLATKV GCNVSDTVEL VECLQKKPYK ELVDQDIQPA RYHIAFGPVI DGDVIPDDPQ ILMEQGEFLN YDIMLGVNQG EGLKFVENIV DSDDGISASD FDFAVSNFVD NLYGYPEGKD VLRETIKFMY TDWADRHNPE TRRKTLLALF TDHQWVAPAV ATADLHSNFG SPTYFYAFYH HCQTDQVPAW ADAAHGDEVP YVLGIPMIGP TELFPCNFSK NDVMLSAVVM TYWTNFAKTG DPNQPVPQDT KFIHTKPNRF EEVAWTRYSQ KDQLYLHIGL KPRVKEHYRA NKVNLWLELV PHLHNLNDIS QYTSTTTKVP STDITFRPTR KNSVPVTSAF PTAKQDDPKQ QPSPFSVDQR DYSTELS
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分子量
72 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NLGN1 (Neuroligin 1) is a crucial synaptic adhesion protein that plays a significant role in the formation and maintenance of synapses in the central nervous system. It is known for its involvement in neuronal communication and synaptic plasticity, impacting cognitive functions such as learning and memory. Mutations and dysregulations of the NLGN1 gene have been implicated in various neurodevelopmental disorders, including autism spectrum disorders and schizophrenia, highlighting its importance in neurobiology. The study of NLGN1 recombinant protein is vital for understanding its structure-function relationship and the mechanisms underlying its role in synaptic transmission. Research efforts involve the expression and purification of NLGN1 to assess its biochemical properties and interactions with other synaptic proteins. Furthermore, elucidating the molecular pathways through which NLGN1 operates can provide insights into potential therapeutic targets for treating synaptic dysfunction-related disorders. Continued investigation into NLGN1 may not only deepen our comprehension of synaptic dynamics but also pave the way for novel interventions in neurodevelopmental and psychiatric diseases.
