Analytical Data
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Gene name
PLEKHA8
- Application
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Alternative Names
FAPP-2; FAPP2; hFAPP2; MGC3358; PH domain-containing family A member 8; Phosphatidylinositol-four-phosphate adapter protein 2; Phosphoinositide binding specificmember 8 ; Phosphoinositol 4 phosphate adaptor protein 2; Phosphoinositol 4-phosphate adapter protein 2; PKHA8_HUMAN; Pleckstrin homology domain containing A8; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8; Pleckstrin homology domain containing family A; Pleckstrin homology domain-containing family A member 8; Plekha8; PLEKHA8 protein ; Serologically defined breast cancer antigen NY-BR-86
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96JA3
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Expression Region
1-519 aa
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AA Sequence
MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV
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Molecular Weight
58.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLEKHA8, a member of the pleckstrin homology (PH) domain-containing protein family, has garnered attention due to its involvement in various cellular processes and its potential role in disease mechanisms. Initially identified as a protein that interacts with phosphoinositides, PLEKHA8 has been implicated in cellular signaling pathways that regulate cytoskeletal dynamics and membrane trafficking. Research has shown that PLEKHA8 may play a critical role in the development and function of various tissues, particularly in the nervous system and immune response. Given its function in cell signaling, alterations in PLEKHA8 expression or activity have been linked to several pathological conditions, including cancer and neurodegenerative diseases. The recombinant protein derived from PLEKHA8 is being studied to elucidate its structure-function relationships, cellular interactions, and effects on cellular physiology. By generating and analyzing recombinant PLEKHA8, researchers aim to better understand its role in health and disease, which could pave the way for novel therapeutic strategies targeting PLEKHA8-related pathways. This research not only contributes to our understanding of cellular mechanisms but also holds promise for identifying potential biomarkers or drug targets within PLEKHA8's signaling network.
