Analytical Data
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基因名
IL23p19
- Application
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别名
IL23p19；Interleukin-23 subunit alpha
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NPF7
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表达区间
23-328aa
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氨基酸序列
IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCSGSTS GSGKPGSGEG STKGRAVPGG SSPAWTQCQQ LSQKLCTLAW SAHPLVGHMD LREEGDEETT NDVPHIQCGD GCDPQGLRDN SQFCLQRIHQ GLIFYEKLLG SDIFTGEPSL LPDSPVGQLH ASLLGLSQLL QPEGHHWETQ QIPSLSPSQP WQRLLLRFKI LRSLQAFVAV AARVFAHGAA TLSP
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分子量
70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IL-23, an important cytokine in the immune response, is composed of two subunits: IL-23p19 and IL-23p40. The IL-23p19 subunit has gained significant attention in immunology and therapeutic research due to its pivotal role in the development and maintenance of inflammatory responses, particularly in autoimmune diseases, such as psoriasis, Crohn's disease, and rheumatoid arthritis. Elevated levels of IL-23 have been implicated in the pathogenesis of these conditions, as it promotes the differentiation and expansion of T-helper 17 (Th17) cells, which are crucial for mediating inflammation. Consequently, targeting IL-23 is a promising strategy for developing novel treatments. The production of recombinant IL-23p19 protein allows researchers to study its biological functions, investigate its interaction with receptors, and evaluate its potential as a therapeutic target. Understanding the structural and functional properties of IL-23p19 through recombinant techniques provides valuable insights into its role in immune regulation and the development of autoimmunity. This research is critical for advancing therapeutic approaches, including monoclonal antibodies and small molecule inhibitors, aimed at modulating IL-23 signaling pathways to alleviate the symptoms of chronic inflammatory diseases. Overall, the study of recombinant IL-23p19 protein is foundational for deciphering its contributions to immune pathology and the development of targeted immunotherapies.
