Analytical Data
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基因名
CSF2
- Application
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别名
CSF2；GMCSF；Granulocyte-macrophage colony-stimulating factor
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P04141
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表达区间
18-144aa
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氨基酸序列
APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQT ITFESFKENL KDFLLVIPFD CWEPVQE
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分子量
15 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSF2, also known as granulocyte-macrophage colony-stimulating factor (GM-CSF), is a crucial cytokine involved in the differentiation and function of myeloid cells, including granulocytes and macrophages. It plays a vital role in immune responses, influencing both innate and adaptive immunity. Research into CSF2 has gained significant attention due to its potential applications in immunotherapy, particularly in cancer treatment, where it can enhance the anti-tumor immune response by stimulating the production and activity of immune cells. Additionally, CSF2 has been investigated for its therapeutic potential in various diseases characterized by immune dysregulation, such as autoimmune disorders and chronic inflammatory conditions. The recombinant form of CSF2 (rCSF2) can be produced through genetic engineering techniques, allowing for controlled studies of its biological activity and therapeutic efficacy. Enhanced understanding of CSF2 signaling pathways and its interaction with other cytokines and immune mechanisms is essential for developing novel treatment strategies. Furthermore, rCSF2 is being explored in clinical trials, showcasing its ability to improve immune responses in patients with certain malignancies or those undergoing immunosuppressive therapies. Overall, the study of CSF2 and its recombinant protein offers promising possibilities for advancing our understanding of immune modulation and for creating innovative therapeutic approaches in various diseases.
