Analytical Data
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Gene name
CSF2
- Application
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Alternative Names
CSF2；GMCSF；Granulocyte-macrophage colony-stimulating factor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P04141
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Expression Region
18-144aa
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AA Sequence
APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQT ITFESFKENL KDFLLVIPFD CWEPVQE
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Molecular Weight
15 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSF2, also known as granulocyte-macrophage colony-stimulating factor (GM-CSF), is a crucial cytokine involved in the differentiation and function of myeloid cells, including granulocytes and macrophages. It plays a vital role in immune responses, influencing both innate and adaptive immunity. Research into CSF2 has gained significant attention due to its potential applications in immunotherapy, particularly in cancer treatment, where it can enhance the anti-tumor immune response by stimulating the production and activity of immune cells. Additionally, CSF2 has been investigated for its therapeutic potential in various diseases characterized by immune dysregulation, such as autoimmune disorders and chronic inflammatory conditions. The recombinant form of CSF2 (rCSF2) can be produced through genetic engineering techniques, allowing for controlled studies of its biological activity and therapeutic efficacy. Enhanced understanding of CSF2 signaling pathways and its interaction with other cytokines and immune mechanisms is essential for developing novel treatment strategies. Furthermore, rCSF2 is being explored in clinical trials, showcasing its ability to improve immune responses in patients with certain malignancies or those undergoing immunosuppressive therapies. Overall, the study of CSF2 and its recombinant protein offers promising possibilities for advancing our understanding of immune modulation and for creating innovative therapeutic approaches in various diseases.
