Analytical Data
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Gene name
PLAGL2
- Application
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Alternative Names
C2H2 type zinc finger protein ; KIAA0198; PLAGL2; PLAL2_HUMAN; Pleiomorphic adenoma gene-like 2; Pleiomorphic adenoma-like protein 2; Zinc finger protein PLAGL2; ZNF900
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UPG8
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Expression Region
1-496 aa
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AA Sequence
MTTFFTSVPP WIQDAKQEEE VGWKLVPRPR GREAESQVKC QCEISGTPFS NGEKLRPHSL PQPEQRPYSC PQLHCGKAFA SKYKLYRHMA THSAQKPHQC MYCDKMFHRK DHLRNHLQTH DPNKEALHCS ECGKNYNTKL GYRRHLAMHA ASSGDLSCKV CLQTFESTQA LLEHLKAHSR RVAGGAKEKK HPCDHCDRRF YTRKDVRRHL VVHTGRKDFL CQYCAQRFGR KDHLTRHVKK SHSQELLKIK TEPVDMLGLL SCSSTVSVKE ELSPVLCMAS RDVMGTKAFP GMLPMGMYGA HIPTMPSTGV PHSLVHNTLP MGMSYPLESS PISSPAQLPP KYQLGSTSYL PDKLPKVEVD SFLAELPGSL SLSSAEPQPA SPQPAAAAAL LDEALLAKSP ANLSEALCAA NVDFSHLLGF LPLNLPPCNP PGATGGLVMG YSQAEAQPLL TTLQAQPQDS PGAGGPLNFG PLHSLPPVFT SGLSSTTLPR FHQAFQ
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Molecular Weight
54.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLAGL2 (PLAG-like 2) is a member of the PLAG gene family, which plays a critical role in cell proliferation, differentiation, and tumorigenesis. Research has shown that PLAGL2 is an important regulator of various developmental processes and has been implicated in several cancers, including breast, colon, and liver cancers. The protein operates primarily as a transcription factor, influencing the expression of genes involved in cellular signaling pathways. Its dysregulation has been linked to oncogenic activities, leading to increased cell growth and resistance to apoptosis. Given the significant role of PLAGL2 in cancer biology, there has been a growing interest in studying its recombinant protein for potential therapeutic applications. Generating PLAGL2 recombinant protein can facilitate a deeper understanding of its functional mechanisms, interaction with other proteins, and its role in malignancy. Furthermore, this protein can serve as a biomarker for cancer diagnosis and prognosis, and its study may provide insights into novel treatment strategies targeting PLAGL2-related pathways. By elucidating the structure-function relationships of PLAGL2, researchers aim to better comprehend its contributions to cancer development and progression, ultimately leading to improved therapeutic approaches.
