Analytical Data
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Gene name
GUCY2C
- Application
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Alternative Names
GUCY2C；GUC2C；STAR；Guanylyl cyclase C
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25092
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Expression Region
24-430aa
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AA Sequence
SQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQ
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Molecular Weight
74.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Guanylate cyclase 2C (GUCY2C) is a receptor that plays a critical role in gastrointestinal physiology by mediating the effects of the endogenous ligands, guanylin and uroguanylin. It is primarily expressed in the intestinal epithelium and regulates fluid and electrolyte balance. Dysregulation of GUCY2C signaling has been implicated in various gastrointestinal disorders, including diarrhea and colorectal cancer. The study of recombinant GUCY2C proteins has gained traction as they offer a valuable tool for understanding the receptor's functional mechanisms, structure, and interaction with its ligands. By producing and characterizing recombinant GUCY2C, researchers can investigate the receptor's signaling pathways, explore its potential as a therapeutic target, and evaluate its role in disease states. Additionally, the recombinant protein can be utilized in the development of diagnostic assays and therapeutic agents, particularly in conditions where GUCY2C activity is altered. Thus, the research involving GUCY2C recombinant proteins not only enhances the understanding of gastrointestinal physiology but also opens avenues for innovative treatments for related diseases.
