Analytical Data
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Gene name
PITPNC1
- Application
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Alternative Names
Cytoplasmic phosphatidylinositol transfer protein 1; M rdgB beta; M-rdgB beta; Mammalian rdgB homolog beta; MrdgBbeta; Phosphatidylinositol transfer protein cytoplasmic 1; PITC1_HUMAN; pitpnc1; RDGB BETA; RDGBB; RDGBB1; RdgBbeta; Retinal degeneration B beta 1; Retinal degeneration B homolog beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UKF7
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Expression Region
1-332 aa
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AA Sequence
MLLKEYRICM PLTVDEYKIG QLYMISKHSH EQSDRGEGVE VVQNEPFEDP HHGNGQFTEK RVYLNSKLPS WARAVVPKIF YVTEKAWNYY PYTITEYTCS FLPKFSIHIE TKYEDNKGSN DTIFDNEAKD VEREVCFIDI ACDEIPERYY KESEDPKHFK SEKTGRGQLR EGWRDSHQPI MCSYKLVTVK FEVWGLQTRV EQFVHKVVRD ILLIGHRQAF AWVDEWYDMT MDDVREFERA TQEATNKKIG IFPPAISISS IPLLPSSVRS APSSAPSTPL STDAPEFLSV PKDRPRKKSA PETLTLPDPE KKATLNLPGM HSSDKPCRPK SE
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Molecular Weight
38.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PITPNC1 (Phosphatidylinositol transfer protein alpha) is a member of the phosphatidylinositol transfer protein family, known to play a crucial role in lipid metabolism and signal transduction. Recent studies have highlighted its involvement in various cellular processes, including membrane dynamics, cell proliferation, and apoptosis. Abnormal expression of PITPNC1 has been linked to several diseases, particularly cancer, where it may contribute to tumorigenesis and metastasis by influencing lipid signaling pathways and membrane composition. The interest in recombinant PITPNC1 proteins has grown as researchers aim to elucidate its biochemical functions and interactions within cellular contexts. Recombinant expression systems, such as bacterial and mammalian systems, are employed to produce PITPNC1 in sufficient quantities for structural and functional analyses. Understanding PITPNC1's role in lipid transfer and its regulatory mechanisms could provide insights into novel therapeutic targets for diseases associated with lipid dysregulation. Overall, the ongoing research on PITPNC1 recombinant proteins holds promise for advancing our understanding of lipid biology and its implications in health and disease.
