Analytical Data
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Gene name
ZCCHC12
- Application
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Alternative Names
ZCCHC12；SIZN1；Zinc finger CCHC domain-containing Protein 12
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6PEW1
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Expression Region
1-402aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZCCHC12 is a member of the zinc finger CCCH-type protein family, which plays a crucial role in various biological processes, including regulation of gene expression, RNA metabolism, and cellular stress responses. Research has shown that ZCCHC12 is involved in modulating the expression of genes associated with tumor growth and progression, making it a potential target for cancer therapy. Its unique structure, characterized by multiple zinc finger motifs, allows it to bind specific RNA molecules, influencing their stability and translation. Understanding the functional mechanisms of ZCCHC12 is essential, as it may provide insights into the underlying molecular pathways that contribute to diseases such as cancer. Additionally, studies have suggested that ZCCHC12 may have implications in other physiological processes such as inflammation and immune responses. Therefore, the recombinant expression and characterization of ZCCHC12 protein are vital steps toward elucidating its biological roles and therapeutic potential. Advanced techniques, including recombinant DNA technology and protein purification, are utilized to produce this protein in substantial quantities for functional assays, structural studies, and potential application in drug development. Thus, ZCCHC12 not only represents an interesting subject of study in molecular biology but also holds promise for the development of novel therapeutic strategies in cancer and other diseases.
