Analytical Data
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Gene name
WWOX
- Application
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Alternative Names
WWOX；FOR；WW domain-containing oxidoreductase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZC7-5
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Expression Region
1-234aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WWOX (WW domain-containing oxidoreductase) is a gene located at chromosome 16q23.3, which is frequently found to be downregulated or deleted in various malignancies, suggesting its potential role as a tumor suppressor. The protein encoded by WWOX is implicated in diverse cellular processes, including signal transduction, apoptosis, and cellular differentiation. Research has shown that WWOX interacts with numerous signaling molecules and transcription factors, influencing pathways such as the Wnt and MAPK pathways, further establishing its significance in cancer biology. Additionally, WWOX has been associated with various neurodegenerative diseases, which adds to its relevance in understanding pathophysiological mechanisms. The functional analysis of recombinant WWOX protein has emerged as a vital area of research, enabling investigators to dissect its biological roles and regulatory mechanisms in the context of diseases. Expression of WWOX in suitable host systems allows for the characterization of its enzymatic activities, the elucidation of its interactions with other proteins, and the exploration of its therapeutic potential. Given the multifaceted roles of WWOX in both tumorigenesis and neurodegeneration, the ongoing study of its recombinant form aims to provide insights that may lead to novel therapeutic strategies and better understanding of its contribution to cellular homeostasis and pathology.
