Analytical Data
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Gene name
ATPBD1B
- Application
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Alternative Names
GPN2; ATPBD1B; UNQ5828/PRO19647; GPN-loop GTPase 2; ATP-binding domain 1 family member B
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H9Y4
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Expression Region
1-310aa
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AA Sequence
MAGAAPTTAF GQAVIGPPGS GKTTYCLGMS EFLRALGRRV AVVNLDPANE GLPYECAVDV GELVGLGDVM DALRLGPNGG LLYCMEYLEA NLDWLRAKLD PLRGHYFLFD CPGQVELCTH HGALRSIFSQ MAQWDLRLTA VHLVDSHYCT DPAKFISVLC TSLATMLHVE LPHINLLSKM DLIEHYGKLA FNLDYYTEVL DLSYLLDHLA SDPFFRHYRQ LNEKLVQLIE DYSLVSFIPL NIQDKESIQR VLQAVDKANG YCFRAQEQRS LEAMMSAAMG ADFHFSSTLG IQEKYLAPSN QSVEQEAMQL
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Molecular Weight
60.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATPBD1B (ATP-binding cassette sub-family D member 1B) is a member of the ATP-binding cassette (ABC) transporter family, which plays a critical role in various cellular processes, including drug transport, lipid metabolism, and cellular signaling. The interest in ATPBD1B has grown due to its potential involvement in various diseases, including cancer and metabolic disorders. Research has indicated that ATPBD1B may influence the proliferation and survival of certain types of cancer cells, making it a relevant target for therapeutic interventions. Additionally, the protein's ability to bind ATP suggests that it may act as an energy-dependent transporter, which could be crucial for cellular homeostasis and function. Understanding the structure and function of ATPBD1B through recombinant protein studies could provide insights into its specific biological roles, mechanisms of action, and potential implications in disease models. Advances in recombinant DNA technology allow for the production of ATPBD1B in sufficient quantities for detailed biochemical characterization and functional assays. As researchers continue to explore the nuances of ATPBD1B, the development of specific inhibitors or modulators could pave the way for novel therapeutic strategies aimed at mitigating the pathophysiological effects associated with its dysregulation. Overall, the ongoing investigation into ATPBD1B serves as a promising avenue for enhancing our understanding of ABC transporters and their impact on human health.
