Analytical Data
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基因名
PHF10
- Application
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别名
BAF45a; BRG1-associated factor 45a; FLJ10975; MGC111009; PHD finger protein 10; PHD finger protein 10; isoform a; PHD zinc finger protein XAP135; Phf10; PHF10_HUMAN; XAP135
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WUB8
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表达区间
2-498 aa
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氨基酸序列
AAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV TSFKRKYPDL ERRDLSHKEK LYLRELNVIT ETQCTLGLTA LRSDEVIDLM IKEYPAKHAE YSVILQEKER QRITDHYKEY SQMQQQNTQK VEASKVPEYI KKAAKKAAEF NSNLNRERME ERRAYFDLQT HVIQVPQGKY KVLPTERTKV SSYPVALIPG QFQEYYKRYS PDELRYLPLN TALYEPPLDP ELPALDSDGD SDDGEDGRGD EKRKNKGTSD SSSGNVSEGE SPPDSQEDSF QGRQKSKDKA ATPRKDGPKR SVLSKSVPGY KPKVIPNAIC GICLKGKESN KKGKAESLIH CSQCENSGHP SCLDMTMELV SMIKTYPWQC MECKTCIICG QPHHEEEMMF CDMCDRGYHT FCVGLGAIPS GRWICDCCQR APPTPRKVGR RGKNSKEG
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分子量
56.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PHF10, a member of the PHD finger protein family, has emerged as a critical player in various biological processes, including gene regulation and chromatin remodeling. Its unique structure, featuring a PHD (plant homeodomain) finger, allows it to interact with specific histone modifications, thereby influencing transcriptional activity and cellular differentiation. Recent research has unveiled its involvement in processes such as DNA damage response and tumorigenesis, suggesting that PHF10 might play a dual role in both normal cellular functions and disease pathways. Given its pivotal role in regulating gene expression, understanding the mechanisms by which PHF10 exerts its effects is essential for elucidating its potential as a therapeutic target. Additionally, the development of recombinant PHF10 protein has enabled researchers to investigate its functional properties in vitro, facilitating insights into its interactions with histones and other regulatory proteins. The study of PHF10 not only contributes to our understanding of chromatin dynamics but also opens new avenues for potential interventions in cancer and other disorders linked to epigenetic dysregulation.
