Analytical Data
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基因名
VPS26A
- Application
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别名
VPS26A；VPS26；Vacuolar Protein sorting-associated Protein 26A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O75436
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表达区间
1-327aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMSFLGGFFGPICEIDIVLNDGETRKMA EMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIE LFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVR LRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIE FEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTET ETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLV LVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM
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分子量
41 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS26A is a crucial component of the retromer complex, which plays a significant role in intracellular trafficking and the recycling of membrane proteins. Research has shown that VPS26A is involved in the transport of cargo from endosomes to the trans-Golgi network, influencing various cellular processes, including nutrient sensing, signaling pathways, and cellular responses to stress. Mutations or dysregulation of VPS26A have been implicated in numerous diseases, particularly neurodegenerative disorders, where impaired protein recycling contributes to toxic protein accumulation. Recent studies have focused on understanding the structural and functional properties of VPS26A, exploring its interactions with other retromer components and downstream effectors to elucidate its role in cargo recognition and trafficking. Additionally, the development of VPS26A as a potential therapeutic target is being investigated, aiming to restore normal trafficking mechanisms in pathological conditions. This protein's significance in maintaining cellular homeostasis underscores the need for comprehensive studies, paving the way for novel approaches in treating diseases associated with retromer dysfunction.
