Analytical Data
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Gene name
VPS26A
- Application
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Alternative Names
VPS26A；VPS26；Vacuolar Protein sorting-associated Protein 26A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75436
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Expression Region
1-327aa
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AA Sequence
MGSSHHHHHHSSGLVPRGSHMGSMSFLGGFFGPICEIDIVLNDGETRKMA EMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIE LFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVR LRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIE FEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTET ETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLV LVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM
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Molecular Weight
41 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS26A is a crucial component of the retromer complex, which plays a significant role in intracellular trafficking and the recycling of membrane proteins. Research has shown that VPS26A is involved in the transport of cargo from endosomes to the trans-Golgi network, influencing various cellular processes, including nutrient sensing, signaling pathways, and cellular responses to stress. Mutations or dysregulation of VPS26A have been implicated in numerous diseases, particularly neurodegenerative disorders, where impaired protein recycling contributes to toxic protein accumulation. Recent studies have focused on understanding the structural and functional properties of VPS26A, exploring its interactions with other retromer components and downstream effectors to elucidate its role in cargo recognition and trafficking. Additionally, the development of VPS26A as a potential therapeutic target is being investigated, aiming to restore normal trafficking mechanisms in pathological conditions. This protein's significance in maintaining cellular homeostasis underscores the need for comprehensive studies, paving the way for novel approaches in treating diseases associated with retromer dysfunction.
