Analytical Data
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Gene name
PFTK2
- Application
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Alternative Names
Cyclin-dependent kinase 15. EC:2.7.11.22. Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein. Cell division protein kinase 15. Serine/threonine-protein kinase ALS2CR7. Serine/threonine-protein kinase PFTAIRE-2
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96Q40
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Expression Region
1-349 aa
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AA Sequence
MTSFHPRGLQAARAQKFKSKRPRSNSDCFQEEDLRQGFQWRKSLPFGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGLKHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDE
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Molecular Weight
66 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PFTK2, or Protein Kinase PFTK2, is a member of the cyclin-dependent kinase (CDK) family, which plays a crucial role in regulating the cell cycle and various cellular processes. Its involvement in cell proliferation and differentiation has drawn significant attention in cancer research, as aberrant expression or activity of CDKs is often linked to tumorigenesis. Previous studies have indicated that PFTK2 may have unique functions distinct from other CDKs, particularly in the context of cellular stress response and apoptosis. Moreover, its potential as a therapeutic target presents an intriguing avenue for the development of novel cancer treatments. Given the complexity of its regulatory mechanisms and the need for precise scientific understanding, the production of recombinant PFTK2 protein is essential for further investigations. This enables researchers to conduct detailed biochemical assays, structural studies, and cell-based experiments to decipher its functional role in cellular mechanisms. As such, the study of recombinant PFTK2 protein not only enhances our understanding of its biological significance but also paves the way for potential applications in targeted therapies, thereby contributing to the broader field of cancer biology and treatment strategies.
