Analytical Data
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基因名
ATP6V0D2
- Application
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别名
ATP6V0D2V-type proton ATPase subunit d 2; V-ATPase subunit d 2; Vacuolar proton pump subunit d 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N8Y2
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表达区间
1-350aa
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氨基酸序列
MLEGAELYFN VDHGYLEGLV RGCKASLLTQ QDYINLVQCE TLEDLKIHLQ TTDYGNFLAN HTNPLTVSKI DTEMRKRLCG EFEYFRNHSL EPLSTFLTYM TCSYMIDNVI LLMNGALQKK SVKEILGKCH PLGRFTEMEA VNIAETPSDL FNAILIETPL APFFQDCMSE NALDELNIEL LRNKLYKSYL EAFYKFCKNH GDVTAEVMCP ILEFEADRRA FIITLNSFGT ELSKEDRETL YPTFGKLYPE GLRLLAQAED FDQMKNVADH YGVYKPLFEA VGGSGGKTLE DVFYEREVQM NVLAFNRQFH YGVFYAYVKL KEQEIRNIVW IAECISQRHR TKINSYIPIL
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分子量
66.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP6V0D2 is a crucial component of the vacuolar ATPase (V-ATPase) complex, which plays a significant role in cellular processes such as pH regulation, protein sorting, and endocytosis. This protein, primarily expressed in dendritic cells and macrophages, has been implicated in the regulation of immune responses and the maintenance of cellular homeostasis. Research has shown that ATP6V0D2 is involved in antigen presentation and influences the activation of T cells, highlighting its importance in the immune system. Dysregulation of ATP6V0D2 has been associated with various diseases, including autoimmune disorders and cancer, making it a potential therapeutic target. Understanding the structure and function of ATP6V0D2 is essential for unraveling its role in cellular mechanisms and developing strategies for disease intervention. Consequently, the generation of recombinant ATP6V0D2 protein has become a focal point for researchers aiming to elucidate its biochemical properties and interactions within the V-ATPase complex. By studying this protein in detail, scientists hope to gain insights into its contributions to immunological functions and its potential as a biomarker or target in therapeutic applications.
