Analytical Data
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基因名
USF1
- Application
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别名
USF1；BHLHB11；Upstream stimulatory factor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22415
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表达区间
1-310aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMKGQQKTAETEEGTVQIQEGAVATGEDPTSVAIASIQSAATFPDPNV KYVFRTENGGQVMYRVIQVSEGQLDGQTEGTGAISGYPATQSMTQAVIQG AFTSDDAVDTEGTAAETHYTYFPSTAVGDGAGGTTSGSTAAVVTTQGSEA LLGQATPPGTGQFFVMMSPQEVLQGGSQRSIAPRTHPYSPKSEAPRTTRD EKRRAQHNEVERRRRDKINNWIVQLSKIIPDCSMESTKSGQSKGGILSKA CDYIQELRQSNHRLSEELQGLDQLQLDNDVLRQQVEDLKNKNLLLRAQLR HHGLEVVIKNDSN
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分子量
36 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USF1, or Upstream Stimulatory Factor 1, is a key transcription factor involved in the regulation of genes associated with lipid metabolism, glucose homeostasis, and insulin signaling. Its role in these metabolic pathways has drawn significant attention, particularly in the context of obesity and type 2 diabetes, conditions that are becoming increasingly prevalent worldwide. Research has shown that polymorphisms in the USF1 gene are linked to metabolic syndrome, indicating its importance in the predisposition to metabolic disorders. Additionally, USF1 interacts with several key metabolic pathways, including those associated with the peroxisome proliferator-activated receptors (PPARs), thereby influencing cellular responses to dietary fat and glucose levels. The study of USF1 and its downstream effects offers valuable insights into the molecular mechanisms underlying metabolic regulation, highlighting its potential as a therapeutic target for metabolic diseases. Overall, understanding the structural and functional properties of USF1, including its protein-protein interactions and effects on gene expression, may contribute to the development of novel strategies for combating metabolic disorders and improving patient outcomes.
