Analytical Data
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Gene name
USE1
- Application
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Alternative Names
USE1；USE1L；Vesicle transport Protein USE1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NZ43
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Expression Region
1-231aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAASRLE LNLVRLLSRC EAMAAEKRDP DEWRLEKYVG ALEDMLQALK VHASKPASEV INEYSWKVDF LKGMLQAEKL TSSSEKALAN QFLAPGRVPT TARERVPATK TVHLQSRARY TSEMRSELLG TDSAEPEMDV RKRTGVAGSQ PVSEKQSAAE LDLVLQRHQN LQEKLAEEML GLARSLKTNT LAAQSVIKKD NQTLSHSLKM ADQNLEKLKT ESERLEQHTQ KSVN
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Molecular Weight
28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
USE1, a member of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein REceptor) protein family, plays a crucial role in intracellular membrane trafficking, particularly in the fusion of vesicles with target membranes. Research into USE1 has gained significance due to its involvement in various cellular processes, including, but not limited to, exocytosis and endocytosis, which are essential for maintaining cellular homeostasis. The characterization of USE1 and its functional mechanisms is critical for understanding how cells regulate communication, nutrient uptake, and waste removal. Dysregulation of USE1 has been linked to several diseases, including neurodegenerative disorders and metabolic syndromes, making it a potential therapeutic target. Recent studies have focused on the structural and functional aspects of USE1, utilizing advanced techniques such as cryo-electron microscopy and X-ray crystallography to elucidate its role in vesicular transport. By investigating USE1 and its interactions with other SNARE proteins, researchers aim to develop innovative strategies to modulate its function in pathological conditions, thereby contributing to the broader field of cell biology and therapeutic intervention. Understanding the intricate dynamics of USE1 is not only pivotal for basic cellular biology but also holds promise for developing novel treatments that could alleviate the burden of diseases associated with impaired intracellular transport.
