Analytical Data
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Gene name
ATMIN
- Application
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Alternative Names
ASCIZ; ATM INteracting Protein; ATM interactor; ATM substrate CHK2-interacting zinc finger Protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43313
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Expression Region
1-667aa
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AA Sequence
MKMHAEKKHKCSKCSNSYGTEWDLKRHAEDCGKTFRCTCGCPYASRTALQSHIYRTGHEIPAEHRDPPSKKRKMENCAQNQKLSNKTIESLNNQPIPRPDTQELEASEIKLEPSFEDSCGSNTDKQTLTTPPRYPQKLLLPKPKVALVKLPVMQFSVMPVFVPTADSSAQPVVLGVDQGSATGAVHLMPLSVGTLILGLDSEACSLKESLPLFKIANPIAGEPISTGVQVNFGKSPSNPLQELGNTCQKNSISSINVQTDLSYASQNFIPSAQWATADSSVSSCSQTDLSFDSQVSLPISVHTQTFLPSSKVTSSIAAQTDAFMDTCFQSGGVSRETQTSGIESPTDDHVQMDQAGMCGDIFESVHSSYNVATGNIISNSLVAETVTHSLLPQNEPKTLNQDIEKSAPIINFSAQNSMLPSQNMTDNQTQTIDLLSDLENILSSNLPAQTLDHRSLLSDTNPGPDTQLPSGPAQNPGIDFDIEEFFSASNIQTQTEESELSTMTTEPVLESLDIETQTDFLLADTSAQSYGCRGNSNFLGLEMFDTQTQTDLNFFLDSSPHLPLGSILKHSSFSVSTDSSDTETQTEGVSTAKNIPALESKVQLNSTETQTMSSGFETLGSLFFTSNETQTAMDDFLLADLAWNTMESQFSSVETQTSAEPHTVSNF
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Molecular Weight
98.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ATMIN, a protein identified as a critical regulator of various cellular processes, has garnered significant attention in recent years due to its involvement in DNA damage response and repair mechanisms. Its name derives from “ATM Interacting Protein,” highlighting its interaction with ATM (Ataxia Telangiectasia Mutated), a key player in the cellular response to DNA damage. Research has shown that ATMIN plays an essential role in mediating cellular responses to genotoxic stress, acting as a transcription factor that regulates genes involved in cell survival and proliferation. The dysregulation of ATMIN and its pathways has been implicated in various pathologies, including cancer and neurodegenerative diseases, making it a potential target for therapeutic intervention. Studies have demonstrated that ATMIN not only facilitates the repair of DNA double-strand breaks but also influences mitochondrial function and cellular metabolism, underscoring its pivotal role in maintaining cellular homeostasis. The exploration of ATMIN's functions and regulatory mechanisms is crucial for understanding its contributions to disease progression and for developing novel strategies for targeted therapies. Thus, ongoing research on ATMIN and its pathways aims to elucidate its diverse roles in cellular health and disease, potentially opening new avenues for clinical applications in oncology and beyond.
