Analytical Data
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Gene name
GNaS1
- Application
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Alternative Names
GNaS1；GNAS1；Guanine nucleotide-binding Protein G(s) subunit alpha isoforms XLas
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P63092
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Expression Region
1-394aa
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AA Sequence
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
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Molecular Weight
61.7kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNaS1, or Gαs subunit of the guanine nucleotide-binding protein (G protein), plays a crucial role in cell signaling pathways by modulating adenylate cyclase activity and thus influencing cellular responses to various hormones and neurotransmitters. Dysregulation of GNaS1 is implicated in several diseases, including endocrine disorders, cardiovascular diseases, and certain types of cancer. The study of GNaS1 recombinant proteins has gained significance as it allows for a detailed understanding of the protein's structure, function, and its interactions with other signaling molecules. Researchers have been focusing on the purification and characterization of GNaS1 to explore its role in G protein-coupled receptor (GPCR) signaling pathways, contributing to the development of therapeutic strategies targeting these pathways. Moreover, advances in recombinant DNA technology have enabled the production of GNaS1 in various expression systems, facilitating in vitro studies and high-throughput screening for potential pharmaceutical compounds. Understanding the functional dynamics of GNaS1 could lead to novel interventions for treating diseases associated with G protein signaling, making it a vital area of research in molecular and cellular biology.
