Analytical Data
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Gene name
UFD1L
- Application
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Alternative Names
UFD1L；UFD1L；Ubiquitin recognition factor in ER-associated degradation Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92890
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Expression Region
1-307aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMFSFNMF DHPIPRVFQN RFSTQYRCFS VSMLAGPNDR SDVEKGGKII MPPSALDQLS RLNITYPMLF KLTNKNSDRM THCGVLEFVA DEGICYLPHW MMQNLLLEEG GLVQVESVNL QVATYSKFQP QSPDFLDITN PKAVLENALR NFACLTTGDV IAINYNEKIY ELRVMETKPD KAVSIIECDM NVDFDAPLGY KEPERQVQHE ESTEGEADHS GYAGELGFRA FSGSGNRLDG KKKGVEPSPS PIKPGDIKRG IPNYEFKLGK ITFIRNSRPL VKKVEEDEAG GRFVAFSGEG QSLRKKGRKP
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UFD1L (Ubiquitin Fusion Degradation 1-Like) is an important protein involved in the ubiquitin-proteasome system, which plays a crucial role in protein degradation and cellular homeostasis. Its primary function is to facilitate the recognition and elimination of misfolded or damaged proteins, thereby maintaining protein quality control within the cell. Mutations in the UFD1L gene have been associated with various developmental disorders and syndromes, highlighting its significance in human health. Given its pivotal role in cellular processes, researchers are increasingly focused on studying the structure and function of recombinant UFD1L proteins. These studies aim to elucidate the molecular mechanisms underlying UFD1L's interaction with other components of the ubiquitin pathway, as well as its involvement in signaling networks. Moreover, understanding how UFD1L operates at a molecular level could provide insights into its role in disease mechanisms and potential therapeutic targets. By producing recombinant UFD1L proteins in the laboratory, researchers can examine its functional properties and regulatory mechanisms, ultimately paving the way for novel interventions in conditions linked to protein mismanagement and associated pathologies.
